The Ibrox side are looking to reach the last four of the competition for the third season in a row.
And the Englishman has made four changes to the team that defeated Motherwell 1-0 in the most recent fixture.
Ridvan Yilmaz, Ryan Jack, Abdallah Sima and Kemar Roofe come into the starting line-up with Borna Barisic, Cyriel Dessers, Rabbi Matondo and Scott Wright dropping out.
Jack Butland starts in goal with a back four of James Tavernier, Connor Goldson, Ben Davies and Ridvan.
Jose Cifuntes, Ryan Jack and John Lundstram start in midfield behind a front three of Sam Lammers, Sima and Roofe.
RANGERS XI: Butland, Tavernier, Goldson, Davies, Ridvan, Lundstram, Jack, Cifuentes, Lammers, Sima, Roofe.
SUBS: McCrorie, Souttar, Dessers, Sterling, Wright, Balogun, Barisic, Rice, McKinnon.
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